Here, we describe a novel method of applying qualitative research methods to free-text comments collected in a large epidemiologic questionnaire. However, methods for the conduct of qualitative research within large samples are underdeveloped. Usually reserved for small samples, qualitative research techniques have the potential to enhance insights gained from large questionnaires and cohort studies, both deepening the interpretation of quantitative data and generating novel hypotheses that might otherwise be missed by standard approaches this is especially true where exposures and outcomes are new, understudied, or rapidly changing, as in a pandemic. Qualitative research methods, while rising in popularity, are still a relatively underutilized tool in public health research.
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